Nasal Vaccine Formulation and Delivery: Potential and ChallengesA presentation by MedImmune at last years Drug Delivery Partnerships. Below you can find a brief overview of the presentation, but download the complete presentation here.
Presentation Overview:
- Why vaccines?
- Vaccines contain an agent resembling a disease-causing agent
- Vaccines are cost-effective for the prevention of ID
- Vaccines elicit immune responses
- Vaccination is one of the most cost-effective investments in global health
- Disease eradication
- Nasal delivery of vaccines
- Promising environment for the delivery of vaccines
- Non-mucosal versus mucosal administration route
- Addresses hurdles faced by other routes of delivery
- Most pathogens enter the body through the mucosal route
- Challenges in the nasal cavity
- Dose volume restrictions
- Mucosal clearance
- Potential enzymatic degradation
- Small anterior anatomy
- Pharmaceutical factors affecting nasal vaccine delivery
- Case study: Validating API
- Future directions
- Vaccine formulation compositions that increase residence time in the NALT
- Intranasal delivery of the vaccine might need to be synchronize with inhalation
- Using anatomically correct nasal models
To view this entire presentation, click here.
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