Thursday, January 16, 2014

Cynapsus' sublingual delivery method helps decrease side effects for Parkinson's drug

Cynapsus' new apomorphine sublingual strip may not be as fast acting as an injection, but studies show this new delivery method helps decrease the side effects of the drug. Apopmorphin is a drug used to help advanced Parkinson's patients transition from their 'off' periods. Many companies have tried to reproduce this drug using new methods, but none of the techniques could get the drug into the bloodstream quick enough.

"One of the limitations of apomorphine is it must be maintained in a highly acidic composition--otherwise it's very unstable," Cynapsus CEO Anthony Giovinazzo told FierceDrugDelivery over the phone from the J. P. Morgan Healthcare Conference in San Francisco. "What our strip system does is allow the drug to remain intact on the strip and change in acidity as it dissolves in the mouth. It allows it to penetrate in two minutes or less and get the drug into the bloodstream."

Although Cynapsus still has to finish initial efficacy and safety studies, the company has already been granted nearly $ 1 million dollars by the Michael J. Fox Foundation to move forward with the approval process. What other types of medication could benefit from this method?

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