Tomas Landh,
Novo Nordisk
Why use nanoparticles? What can they do?
- -Overcome solubility
- -Stability issues
- -Limitations on route of administration
- -Biocompartementalization
- -Side effects of generalization drug administration
The size
offers tremendous opportunities in chemistry.
It is critical to realize how enormously small these nanoparticles
are. You can build nanoparticle by aggregating
them into macroparticles.
What is
forgotten when it comes to nano-particles?
Among other things, often the shape, specifically the forms of the
particle and topology. Topology, to this
point, is a field that is largely unexplored.
Some examples of nanocarriers are
micelles, vesicles, nanocapules, nanosphere, and dendrimers. They
are all spherical in shape. When looking
to dive deeper in the field, Landh suggests meeting and conversing with the
universities known for that study. On
place to do this is through science forums.
Surprisingly, China is one of the countries most interested in
nanoparticles and on the forefront of the technology.
What is one
of the biggest challenges for manufactures of the nanoparticles? Human resources. Often times, the best minds choose to go into
other fields such as electornics. If you
build your particles from bottom up by self-assembly, you’ll do very little
harm to your API.
Mahesh Chaubal, Baxter Healthcare
Nanotechnology’s
definition has been debated for a while.
The usual definition of a nano particle is any that are <1
micron. Interestingly, for the most
part, Pharma’s products don’t fit in the nano definition. The benefit of nanotechnology is the ability
to target places that can otherwise not be reached.
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